Raman spectroscopy - advanced optical analysis technology
Boost plant safety, ensure product quality, and optimize operations. Raman spectroscopy measures the composition and molecular structure of your samples from lab-to-process in real time.
This product is not available in this region.
Please contact your Endress+Hauser sales partner for any further questions.
Specs at a glance
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Wetted materials
Body: 316L stainless steel
Window: Proprietary material, optimized for bioprocesses
Surface finish: Ra 15 with Electropolish to ASME BPE SF4 finish
Adhesive: USP Class VI and ISO 10993 compatible -
Immersible length
120 or 220 mm
4.73 or 8.67 inch -
Sterilization method
Autoclave, gamma irradiation
Field of application
The bio sleeve is a critical consumable part for easy, real-time bioprocess measurements with maximum sterility and efficiency. It connects to a reusable, automatically aligned multi optic which pairs with an Rxn-10 probe. The system reduces maintenance and cross-contamination risk for reusable or single-use benchtop bioreactor setups.
Benchtop bioreactors to measure glucose, lactate, amino acids, cell density, titer and more
Benchtop fermenters to measure glycerol, methanol, ethanol, sorbitol, biomass, and more
Use with flow assembly CYA680 for select downstream bioprocessing applications
Benefits
Improved ease of use and reduced maintenance
Autoclavable, gamma sterilizable, and compatible with standard cleaning protocols
Simplified workflow for greater process efficiency – swap out probes mid-batch, use multiple sleeves in the same reactor for simplified redundancy, and calibrate / verify probes at any time
120 mm version is compatible with Endress+Hauser flow assembly CYA680
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Standard products
- Reliable, robust and low-maintenance
Technical excellence
Simplicity
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Specialized products
- Designed for demanding applications
Technical excellence
Simplicity
Variable
| FLEX selections | Technical excellence | Simplicity |
|---|---|---|
Fundamental selection Meet your basic measurement needs |
Technical excellence
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Simplicity
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Lean selection Handle your core processes easily |
Technical excellence
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Simplicity
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Extended selection Optimize your processes with innovative technologies |
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Xpert selection Master your most challenging applications |
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34 documents
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Technical Information (TI)
Accessory optics for the Rxn-10 probe Technical Information
System design and specifications for Rxn-10 probe optics:
Raman immersion optics (KIO1),
non-contact optics (KNCO1), bIO-Optics (KLBIO1),
bio multi optics (KRBMO), bio sleeves (KRBSL),
and Raman optic system for single use (KRSU1)EN 31/05/202303/08/2022Language:
English
Version:
31/05/2023
File size:
467.9 KB
File name:
TI01635CEN_0322.pdf
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Technical Information (TI)
Multi optic calibration and verification kit Technical Information
System design and specifications for the multi optic calibration
and verification kitEN 26/06/2023Language:
English
Version:
26/06/2023
File size:
478.7 KB
File name:
TI01719CEN_0123 Multi optic calibration and verification kit.pdf
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Technical Information (TI)
Rxn-10 Raman spectroscopic probe Technical Information
System design and specifications for the Raman Rxn-10 probe
EN 08/09/202513/11/202431/05/202313/09/202208/09/2021Language:
English
Version:
08/09/2025
File size:
949 KB
File name:
TI01629CEN_0525.pdf
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Operating Instruction (BA)
Accessory optics for the Rxn-10 probe Operating Instructions
Commissioning, operation, and maintenance details
for Rxn-10 probe optics: Raman immersion optics (KIO1),
non-contact optics (KNCO1), bIO-Optics (KLBIO1),
bio multi optics (KRBMO), bio sleeves (KRBSL)
and Raman optic system for single use (KRSU1)EN 31/05/202303/08/202214/09/2021Language:
English
Version:
31/05/2023
File size:
1.8 MB
File name:
BA02171CEN_0322.pdf
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Operating Instruction (BA)
Multi optic calibration and verification kit Operating Instructions
Commissioning, operation, and maintenance details for the
multi optic calibration and verification kitEN 26/06/2023Language:
English
Version:
26/06/2023
File size:
996.4 KB
File name:
BA02294CEN_0123 Multi optic calibration and verification kit.pdf
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Operating Instruction (BA)
Rxn-10 Raman spectroscopic probe Operating Instructions
Commissioning, operation, and maintenance details
for the Raman Rxn-10 probeEN 08/09/202502/12/202431/05/202313/09/202208/09/2021Language:
English
Version:
08/09/2025
File size:
1.8 MB
File name:
BA02160CEN_0525.pdf
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Short Instruction (KA)
Rxn-10 Raman spectroscopic probe Brief Operating Instructions
Quick start guide for the Raman Rxn-10 probe
EN 02/12/202431/05/202313/09/202208/09/2021Language:
English
Version:
02/12/2024
File size:
1.6 MB
File name:
KA01546CEN_0424.pdf
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Short Instruction (KA)
Accessory optics for the Rxn-10 probe Brief Operating Instructions
Quickstart guide for Rxn-10 probe optics:
Raman immersion optics (KIO1),
non-contact optics (KNCO1), bIO-Optics (KLBIO1),
bio multi optics (KRBMO), bio sleeves (KRBSL),
and Raman optic system for single use (KRSU1)EN 31/05/202303/08/202214/09/2021Language:
English
Version:
31/05/2023
File size:
1 MB
File name:
KA01551CEN_0322.pdf
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PU (Publication)
Biopharma 4.0 model graphic
Graphic illustrating the core elements of Biopharma 4.0 including
product lifecycle stages, role of PAT/QbD, and 12 key advanced
technologies for scientists and process engineers in the Life
Sciences, applicable to Raman spectroscopy systems (Raman
Rxn2, Raman Rxn4, Rxn-10, Rxn-45, Rxn-46, bio multi optic and
sleeve, flow cell and flow bench, Raman optic system for single
use, and Raman calibration & verification kits).Language:
English
Version:
22/05/2025
File size:
481.6 KB
File name:
PU01614CEN_0125.pdf
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PU (Publication)
Top must-read Biopharma 4.0 articles - Stay informed about the latest research embracing Biopharma 4.0 principles
A list of published technical articles related to Biopharma 4.0
topics with recommendations from Life Science industry experts
at Endress+Hauser.Language:
English
Version:
26/06/2025
File size:
363.4 KB
File name:
PU01611CEN_0125.pdf
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PU (Publication)
Endress+Hauser - ライフサイエンス技術のワンストップパートナー
Endress+Hauserが、ライフサイエンス分野の専門知識と、ラマン分
光システム（Raman Rxn2、Raman Rxn4、Rxn-10、Rxn-45、Rxn-46、
バイオマルチオプティックおよびスリーブ、フローフィル、フロー
ベンチ、シングルユース用Ramanオプティックシステム）や水質分
析センサ技術（Liquiline CM44P、CM442、OUSAF44、OUSBT66、
Memosens CPS61E、CLS82E、COS81E、CLS82E）などの信頼性の高い
インラインおよびリアルタイム測定技術によって、世界トップクラ
スのバイオ医薬品メーカーから信頼されている理由を強調したグラ
フィック。Language:
Japanese
Version:
04/10/2024
File size:
2.5 MB
File name:
PU01585CJA_0124_Graphic_EH biopharma trust.pdf
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PU (Publication)
Prioritize scalability for an efficient biopharmaceutical product development lifecycle
This technical paper studies the importance of scalability as a
competitive advantage in bioprocessing in the Life Science industry,
and Endress+Hauser's scalable Raman systems (Raman Rxn2,
Raman Rxn4, Rxn-10, Rxn-45, Rxn-46, bio multi optic and sleeve,
flow cell and flow bench, Raman optic system for single use) and
liquid analysis sensor technology and Liquid Analysis portfolio
(Liquiline CM44P, CM442 and OUSAF44, OUSBT66 and
Memosens CPS61E, CLS82E, COS81E, CLS82E).Language:
Czech
Version:
06/09/2024
File size:
381.4 KB
File name:
PU01584CEN_0124_cz_view.pdf
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PU (Publication)
Biopharma 4.0 model graphic (full version)
Expanded version of a graphic illustrating the core elements of
Biopharma 4.0 including product lifecycle stages, role of
PAT/QbD, and 12 key advanced technologies for scientists and
process engineers in the Life Sciences, applicable to Raman
spectroscopy systems (Raman Rxn2, Raman Rxn4, Rxn-10,
Rxn-45, Rxn-46, bio multi optic and sleeve, flow cell and flow
bench, Raman optic system for single use, and Raman calibration
& verification kits).Language:
English
Version:
22/05/2025
File size:
29.1 MB
File name:
PU01613CEN_0125.pdf
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PU (Publication)
ライフサイエンスにおけるラボからプロセスまでの監視と制御 バイオプロセスの物理的・化学的特性の信頼性の高い測定
この製品リストは、ライフサイエンス業界におけるバイオプロセス
用途向けに、光学分析および液体分析の両方から提供される分析機
器をまとめたものです。含まれる製品には、Raman Rxn2アナライザ
、Raman Rxn4アナライザ、Rxn-10プローブ、バイオマルチオプティ
ックおよびバイオスリーブ、ラマンフローアセンブリ、Rxn-45プロ
ーブ、Rxn-46プローブ、シングルユース向けラマンオプティックシ
ステム、Memosens CPS61E、Memosens COS81E、OUSBT66、Memosens
CPS77E、Memosens CLS82E、OUSAF44、Memosens CPS11E、Memosens
CLS16E、TOCアナライザーCA79、Liquiline変換器プラットフォーム
、およびMemobaseソフトウェアが含まれています。Language:
Japanese
Version:
24/08/2025
File size:
1.2 MB
File name:
PU01484CJA_0224_Lab-to-Process Control in Life Sciences.pdf
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PU (Publication)
効率的なバイオ医薬品の製品開発ライフサイクルのために拡張性を優先
この技術文書では、ライフサイエンス産業におけるバイオプロセス
の競争優位性としての拡張性の重要性と、Endress+Hauserの拡張性
のあるラマンシステム（Raman Rxn2、Raman Rxn4、Rxn-10、Rxn-45
、Rxn-46、バイオマルチオプティックおよびスリーブ、フローフィ
ル、フローベンチ、シングルユース用Ramanオプティックシステム）
、水質分析センサ技術、および水質分析製品ラインナップ
（LiquilineCM44P、CM442、OUSAF44、OUSBT66、Memosens CPS61E、
CLS82E、COS81E、CLS82E）について考察しています。Language:
Japanese
Version:
04/10/2024
File size:
1.2 MB
File name:
PU01584CJA_0124_Scalability in biopharma development.pdf
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PU (Publication)
The Biopharma 4.0 glossary - Test your Biopharma 4.0 IQ
A list of definitions and sources for frequently used terms and
abbreviations in the biopharmaceutical industry related to
Biopharma 4.0.Language:
English
Version:
17/06/2025
File size:
445 KB
File name:
PU01610CEN_0125.pdf
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PU (Publication)
Lab-to-process monitoring & control in Life Sciences - Reliable measurement of bioprocess physical and chemical properties
A combined product list of analysis offerings from both Optical Analysis
and LIquid Analysis for bioprocessing applications in the life science
industry (including Raman Rxn2 analyzer, Raman Rxn4 analyzer,
Rxn-10 probe, bio multi optic and bio sleeve, Raman flow assembly,
Rxn-45 probe, Rxn-46 probe, Raman optic system for single use,
Memosens CPS61E, Memosens COS81E, OUSBT66, Memosens CPS61E,
Memosens CPS77E, Memosens CLS82E, OUSAF44, Memosens CPS11E,
Memosens CLS16E, TOC Analyzer CA79, Liquiline transmitter platform, and
Memobase software).Language:
English
Version:
11/04/2024
File size:
776.1 KB
File name:
PU01484CEN_0224.pdf
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PU (Publication)
Endress+Hauser - your one-source Life Sciences technology partner
Graphic highlighting why Endress+Hauser is trusted by the
world's top biopharmaceutical manufacturers for its Life
Sciences expertise and reliable inline, real-time measurement
technologies like Raman spectroscopy systems (Raman Rxn2,
Raman Rxn4, Rxn-10, Rxn-45, Rxn-46, bio multi optic and sleeve,
flow cell and flow bench, Raman optic system for single use) and
liquid analysis sensor technology (Liquiline CM44P, CM442 and
OUSAF44, OUSBT66 and Memosens CPS61E, CLS82E, COS81E,
CLS82E).Language:
Czech
Version:
06/09/2024
File size:
353 KB
File name:
PU01585CEN_0124_cz_view.pdf
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Competence Brochure (CP)
Präzision der Raman-Single-Use-Messung
Zusammensetzungsanalyse in Echtzeit
für die biopharmazeutische Entwicklung
und Herstellung mit dem Endress+Hauser
Raman-Rxn-Portfolio.Language:
German
Version:
24/09/2025
File size:
1.3 MB
File name:
CP01586CDE_0124_Raman_Single_Use_ebook.pdf
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Competence Brochure (CP)
Raman single-use measurement precision
Portfolio Raman Rxn per l'analisi
della composizione in tempo reale
nelle fasi di sviluppo e produzione
nell'industria biofarmaceuticaLanguage:
Italian
Version:
07/05/2025
File size:
2 MB
File name:
CP01586CIT_0124.pdf
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Competence Brochure (CP)
市場投入の加速、歩留まりの増加、品質の向上 Raman RxnシステムとMemosensデジタルセンサによる、ラボからGMP までのリアルタイムでのインラインバイオプロセス監視と制御
この eBook では、ライフサイエンス業界におけるラマン分光シス
テム (Raman Rxn2、Raman Rxn4、Rxn-10、Rxn-45、Rxn-46、バイオ
マルチオプティックおよびスリーブ、フローセルおよびフローベン
チ、シングルユース向けラマンオプティックシステム) や水質分析
センサ技術 (Liquiline CM44P、CM442、OUSAF44、OUSBT66、
Memosens CPS61E、CLS82E、COS81E、CLS82E) を含む、バイオプロ
セス向けの Endress+Hauser インライン分析製品ラインナップを紹
介しています。Language:
Japanese
Version:
02/12/2024
File size:
5.7 MB
File name:
CP01579CJA_0124_Fast-entry-yields_Inline-monitoring_Raman-Memosens.pdf
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Competence Brochure (CP)
Raman single-use measurement precision - Real-time composition analysis for biopharmaceutical development and manufacturing with the Raman Rxn portfolio
An eBook highlighting our Raman spectroscopy reusable and
single-use bioprocessing portfolio (including the Raman Rxn2
analyzer, Raman Rxn4 analyzer, Rxn-10 probe, Rxn-46 probe,
Raman single use optic system, bio multi optic, and bio sleeve),
powered by Kaiser Raman technology.Language:
English
Version:
29/08/2024
File size:
1.2 MB
File name:
CP01586CEN_0124.pdf
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Competence Brochure (CP)
Faster market entry, higher yields, and improved quality - Real-time, inline bioprocess monitoring and control from lab to GMP with Raman Rxn systems & Memosens digital sensors
This eBook highlights the Endress+Hauser inline analysis portfolio
for bioprocessing including Raman spectroscopy systems
(Raman Rxn2, Raman Rxn4, Rxn-10, Rxn-45, Rxn-46, bio multi optic
and sleeve, flow cell and flow bench, Raman optic system for single use)
and liquid analysis sensor technology (Liquiline CM44P, CM442 and
OUSAF44, OUSBT66 and Memosens CPS61E, CLS82E, COS81E, CLS82E)
in the Life Science industry.Language:
English
Version:
21/06/2024
File size:
1.9 MB
File name:
CP01579CEN_0124.pdf
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-
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Competence Brochure (CP)
Faster market entry, higher yields, and improved quality - Real-time, inline bioprocess monitoring and control from lab to GMP with Raman Rxn systems & Memosens digital sensors
This eBook highlights the Endress+Hauser inline analysis portfolio
for bioprocessing including Raman spectroscopy systems
(Raman Rxn2, Raman Rxn4, Rxn-10, Rxn-45, Rxn-46, bio multi optic
and sleeve, flow cell and flow bench, Raman optic system for single use)
and liquid analysis sensor technology (Liquiline CM44P, CM442 and
OUSAF44, OUSBT66 and Memosens CPS61E, CLS82E, COS81E, CLS82E)
in the Life Science industry.Language:
Czech
Version:
06/09/2024
File size:
1.7 MB
File name:
CP01579CEN_0124_cz_view.pdf
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Competence Brochure (CP)
高精度のラマンシングルユース測定 バイオ医薬品の開発および製造のためのRaman Rxn 製品ラインナッ プによるリアルタイム組成分析
このeBookでは、Kaiser Ramanテクノロジーを搭載したラマン分光
法の再利用可能およびシングルユースバイオプロセス製品ラインナ
ップ（Raman Rxn2アナライザ、Raman Rxn4アナライザ、Rxn-10プロ
ーブ、Rxn-46プローブ、シングルユース向けラマンオプティックシ
ステム、バイオマルチオプティック、バイオスリーブ）について紹
介しています。Language:
Japanese
Version:
24/08/2025
File size:
3.7 MB
File name:
CP01586CJA_0124_Raman single-use measurement precision.pdf
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Innovation (IN)
Raman technology in bioprocessing - Scalable in situ bioprocess monitoring enabling advanced process control
An overview brochure about our Raman spectroscopy analyzer
and probe portfolio, powered by Kaiser Raman technology, for
the bioprocessing / biopharmaceutical industry (including the
Raman Rxn2 analyzer, Raman Rxn4 analyzer, Rxn-10 probe,
Rxn-45 probe, Rxn-46 probe, and probe accessory optics (bIO-Optic,
Raman single use optic system, bio multi optic with bio sleeve, and
Raman flow assembly), powered by Kaiser Raman technology.Language:
English
Version:
19/06/2023
File size:
6.8 MB
File name:
IN01228CEN_0223.pdf
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Innovation (IN)
バイオプロセスにおけるラマン技術 - 拡張性のあるin situバイオプロセス監視と高度なプロセス制御
Kaiserラマンテクノロジーを搭載した、バイオプロセス/バイオ医
薬品業界向けのラマン分光アナライザーとプローブ製品ラインナッ
プ（ラマンRxn2アナライザー、ラマンRxn4アナライザー、Rxn-10プ
ローブ、Rxn-45プローブ、Rxn-46プローブ、プローブオプティック
アクセサリ（bIOオプティック、シングルユース向けラマンオプテ
ィックシステム、バイオマルチオプティックおよびバイオスリーブ
と組合せ、ラマンフローアセンブリを含む）の概要パンフレット。Language:
Japanese
Version:
02/08/2024
File size:
7.2 MB
File name:
IN01228CJA_0223_Raman technology in bioprocessing.pdf
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Innovation (IN)
Raman single-use technology for bioprocessing - Real-time composition analysis for biopharmaceutical development and manufacturing
An overview brochure about our Raman spectroscopy multi use and
single use bioprocessing portfolio (including the Raman Rxn2 analyzer,
Raman Rxn4 analyzer, Rxn-10 probe, Rxn-46 probe, Raman single use
optic system, bio multi optic, and bio sleeve), powered by Kaiser Raman
technology.Language:
English
Version:
13/12/2023
File size:
4 MB
File name:
IN01267CEN_0223.pdf
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Innovation (IN)
バイオプロセス用のラマンシングルユース技術 - バイオ医薬品の開発および製造のためのリアルタイム組成分析
Kaiserラマンテクノロジーを採用したラマン分光法マルチユースお
よびシングルユースバイオプロセス用製品ラインナップ（ラマン
Rxn2アナライザー、ラマンRxn4アナライザー、Rxn-10プローブ、
Rxn-46プローブ、シングルユース向けラマンオプティックシステム
、バイオマルチオプティック、バイオスリーブを含む）の概要パン
フレット。Language:
Japanese
Version:
02/08/2024
File size:
5.8 MB
File name:
IN01267CJA_0223_Raman_single-use_Tech_BioProc.pdf
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Innovation (IN)
Raman-Single-Use-Technologie für Bioprozesse Analyse der Zusammensetzung in Echtzeit für biopharmazeutische Entwicklung und Herstellung
Eine Übersichtsbroschüre über unser Raman-Spektroskopie-Portfolio
für die Multi- und Single-use Verwendung in der Bioprozessierung
(einschließlich Raman Rxn2-Analysator, Raman Rxn4-Analysator,
Rxn-10-Sonde, Rxn-46-Sonde, Raman Single-Use-Optiksystem,
Bio-Multioptik und Bio-Sleeve), basierend auf der
Kaiser Raman-Technologie.Language:
German
Version:
10/03/2026
File size:
1.4 MB
File name:
IN01267CDE_0223_Raman-Single-Use_web.pdf
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